منابع مشابه
A David promoter with Goliath strength.
In this issue of Blood, Nair et al report on a computationally derived hepatocyte-specific cis-regulatory module (HS-CRM8) to accomplish high tissue-specific expression in gene therapy for hemophilia. When HS-CRM8 is introduced upstream of a minimal liver-specific promoter in an adenoassociated virus (AAV) that expresses a codon-optimized hyperactive human factor IX (FIX) mutant (FIX Padua), it...
متن کاملDavid and Goliath : Computing the Rank of Sparse Matrices
We want to achieve eecient exact computations, such as the rank, of sparse matrices over nite elds. We therefore compare the practical behaviors of the deterministic Gaussian elimination technique, even with reordering heuristics, with the probabilistic, matrix-free, Wiedemann algorithm.
متن کاملHow David beat Goliath: History of physicians fighting frivolous lawsuits
Legal and medical professions are intertwined in an intimate and complex relationship. Medical malpractice arguably constitutes the biggest point of contention between the two professions. While a significant proportion of medical malpractice complaints are not frivolous and are based on appropriate research and screening criteria, most of these complaints are ultimately settled or taken to tri...
متن کاملDavid V. Goliath: Mauritius facing up to China
Recent studies of the impact of China’s rise on the economies of sub-Saharan Africa generally find that the resource-rich countries of the sub-continent will gain while those that compete with China in export markets will invariably lose. Mauritius, with no exploitable natural resources, and facing acute Chinese competition in its traditional markets, is a most likely candidate to suffer China’...
متن کاملNuclear Pores: David and Goliath in nuclear transport
Ran is the only known member of the Ras superfamily of small GTP-binding proteins to be localized primarily inside the nucleus, and there is considerable evidence that Ran is closely involved in the traffic of macromolecules into and out of the nucleus [1,2]. Ran has been shown to be an essential factor for nuclear import in digitonin-permeabilized cells, and mutant forms of Ran inhibit both pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Land Use Policy
سال: 2010
ISSN: 0264-8377
DOI: 10.1016/j.landusepol.2009.04.003